Pharmacokinetic parameters
| Parameter | Equation | Note |
|---|---|---|
| Half-life | Vd x 0.7 / CL | Steady-state concentration is achieved in 4-5 half-lives |
| Maintenance dose | C ss x CL x dosing interval | Maintenance dose is decreased in patients with renal or hepatic impairment |
| Loading dose | Vd x Css | Loading dose is affected by body weight and composition |
CL = drug clearance
Css = steady-state plasma concentration
Vd = volume of distribution