Selective estrogen receptor modulators
Contents
Drugs
- Tamoxifene
- Raloxifene
MOA
- Competitive inhibitor of estrogen binding
- Mixed agonist/antagonist action
Indications
- Prevention of breast cancer in high-risk patients
- Tamoxifene: adjuvant treatment of breast cancer
- Raloxifene: postmenopausal osteoporosis
Adverse effects
- Hot flashes
- Venous thromboembolism
- Endometrial hyperplasia & carcinoma (tamoxifen only)t