Drugs Tamoxifene Raloxifene MOA Competitive inhibitor of estrogen binding Mixed agonist/antagonist action Indications Prevention of breast cancer in high-risk patients Tamoxifene: adjuvant treatment…

Parameter Equation Note Half-life Vd x 0.7 / CL Steady-state concentration is achieved in 4-5 half-lives Maintenance dose C ss x CL x dosing interval Maintenance dose is decreased in patients with…

Etiology Immunologic response to inhaled antigen (mold, animal protein and etc.) Clinical presentation Acute Chronic Abrupt-onset fever, chills, cough, dyspnea, fatigue, leukocytosis Progressive…

Type Note Nontreponemal (RPR, VDRL) - Antibody to cardiolipin-cholesterol-lecithin antigen- Lower sensitivity in early infection Treponemal (FTA-ABS, TP-EIA) - Antibody to treponemal antigens -…